Euro-Pharmacies Clomixin 20 tabs (50 mg/tab)

Clomiphene Citrate – Кломид

Clomiphene citrate, commonly known as Кломид, is a synthetic non-steroidal medication closely resembling estrogen in structure. Recognized for its effectiveness as an ovulatory stimulant, Clomid interacts with estrogen receptors in the hypothalamus, blocking it from detecting “true” estrogen. This activity prompts the pituitary gland to release increased levels of gonadotropins, such as FSH and LH, which consequently stimulates the ovaries and testes to generate more estrogen and testosterone, respectively.

The utility of Clomiphene has been pivotal for women experiencing ovarian failure and those seeking to induce ovulation. However, it is essential to note that prolonged usage may elevate the risk of ovarian cancer.

Фармакология

Recommended primarily for women with ovulatory dysfunction, Clomid is often prescribed following comprehensive menstrual cycle evaluations. Conditions affecting ovulation include polycystic ovarian syndrome and certain cases of amenorrhea without identifiable causes. Once ovulation is confirmed, Clomid is typically administered starting on the 5th day of the cycle, for a duration of 3-6 cycles.

Начин на действие

As a potent fertility agent, Clomiphene imitates estrogen, blocking estrogen receptors in the hypothalamus. This leads the brain to perceive low estrone levels, which triggers a surge in gonadotropins, enhancing steroid production in both the adrenal glands and ovaries. This surge in estrogen is crucial for successful fertilization.

Показания

Clomid is advised solely for women with ovulatory dysfunction, conditioned on the following criteria:

• The female is not pregnant.
• No presence of ovarian cysts, confirmed through ultrasound.
• Absence of vaginal bleeding; thorough examination required if bleeding occurs.
• All patients must have normal liver function tests.
• Clomid’s efficacy in male infertility remains largely unstudied, although isolated reports suggest it may enhance sperm count under certain conditions.
• Careful prescription of dosage for infertility is crucial.

Clomiphene is a large molecule, soluble in many organic solvents including alcohol, and available in 50 mg tablet form. Before initiating treatment, patients should undergo thorough evaluations for all gynecological and endocrine disorders. Ovulation generally occurs 5-10 days post-initiation of Clomid, and coitus should align with the anticipated ovulation period.

Изграждане на тяло

Clomid is frequently misused by athletes, alongside a variety of other performance-enhancing substances such as анаболни стероиди, HCG, tamoxifen, and thyroid hormones. Unlike typical anabolic steroids, Clomid does not suppress testosterone levels; rather, it promotes a surge in LH, boosting testosterone levels.

Most anabolic steroids possess both androgenic and anabolic effects and may convert to estrogen, leading to gynecomastia in bodybuilders. Clomid serves to inhibit this estrogen-related side effect, enhancing testosterone production while blocking estrogen receptors. Athletes often use Clomid to maximize these benefits, sometimes in conjunction with steroids and growth hormones.

Дозировка на Кломид за спортисти

Administered once daily, Clomid is frequently used either alone or in combination with low-potency anabolic steroids. Athletes commonly initiate Clomid therapy immediately after steroid use, typically within 7-10 days. Recommended dosages range from 50-100 mg/day for a two-week period, with adjustments made based on individual response. Due to the lack of medical endorsement for bodybuilding purposes, insights from fertility experts familiar with Clomid may be beneficial.

Странични ефекти

Clomid is generally safe at recommended dosages for short durations; however, common transient side effects may occur:

• Flushing
• Abdominal discomfort
• Nausea and vomiting
• Breast tenderness
• Headaches
• Abnormal vaginal bleeding
• General fatigue
• Косопад
• Visual disturbances

Of significant concern is the potential for vision changes, stemming from hypothalamic stimulation of the pituitary gland. If such changes occur, immediate cessation of Clomid is necessary, and an ophthalmologist should be consulted.

Mood Changes

Mood alterations, including depression, anxiety, and aggression, have been reported among long-term users. Despite these risks, clinical studies indicate that significant side effects arise in less than 1% of women.

Разходи

Clomid requires a prescription for infertility treatment, yet it is accessible online without one, generally costing between $50-100 for 100 tablets (25-50 mg).

Нива

Availability of Clomid remains widespread; however, most professional sporting organizations categorize it as a banned substance. Detection in urine continues for 5-12 days following use, with sophisticated tests measuring testosterone and estrogen ratios indicating potential abuse of the drug.