Anfarm Hellas Clomiphene Citrate 24 tabs (50 mg/tab) UDLØB

Clomifencitrat - Clomid

Clomiphene Citrate, known as Clomid, is a synthetic, non-steroidal medication closely resembling estrogen. It is extensively utilized as an ovulatory stimulant. Thanks to its structural similarity, Clomiphene effectively binds to estrogen receptors in the hypothalamus, preventing the detection of “real” estrogen, which encourages the pituitary to enhance the release of Gonadotropins like FSH and LH. These hormones thus stimulate the ovaries and testes, promoting additional production of estrogen and testosteron.

This mechanism is particularly valuable for treating women experiencing ovarian failure and aiding in ovulation. However, prolonged usage raises concerns regarding an increased risk of ovarian cancer.

Farmakologi

Clomid is primarily prescribed for women with ovulatory dysfunction. Those struggling to conceive may experience irregularities in their ovulation cycle. Common causes include polycystic ovarian syndrome and unexplained amenorrhea. Before initiating Clomid treatment, a comprehensive evaluation of the menstrual cycle is required to pinpoint dysfunction. Timing is crucial; body temperature and blood tests are monitored to confirm the occurrence of ovulation.

Typically, Clomid begins around the 5th day of the menstrual cycle and is usually used for 3-6 cycles. Extended therapy is not advised.

Virkemåde

Clomid is a potent medication that, when appropriately dosed for short periods, assists women struggling with infertility. Mimicking estrogen, Clomiphene competes with estrogen receptors in the hypothalamus, signaling a decreased level of estrone. This triggers a surge in Gonadotropins, which amplifies ovarian stimulation and elevates estrogen production, crucial for fertilization.

Indikationer

Clomid is intended exclusively for women facing ovulatory dysfunction and must meet these specific criteria:

• Must not be pregnant
• Absence of ovarian cysts confirmed by ultrasound
• No vaginal bleeding; a thorough examination is needed to rule out cancer
• Normal liver function tests
• While Clomid has shown promise for female infertility, its effects on male infertility are less understood. Limited use in males has suggested potential benefits in boosting LH and FSH, leading to increased sperm counts. However, long-term effects in males may result in testicular tumors and mild gynecomastia.
• Prescribed dosage for infertility

Clomiphene, a sizable molecule, is soluble in many organic solvents, including alcohol, while its sodium salt citrate dissolves in water. This chemical is odorless and is available as a 50 mg tablet.

Patients must undergo thorough assessments for any gynecological and endocrine disorders prior to Clomid treatment. Ovulation typically occurs 5-10 days after initiation, with coitus timed to coincide with this period.

Bodybuilding

Clomid is frequently misused by athletes, both amateur and professional, often alongside anabolic steroids, HCG, tamoxifen, and thyroid hormones. Unlike anabolic steroids, Clomid does not reduce testosterone levels; instead, it stimulates LH release, enhancing testosterone production.

While most anabolic steroids feature both androgenic and anabolic properties, some possess mild estrogenic activity, potentially leading to gynecomastia among bodybuilders. To counteract this, Clomid is utilized to inhibit estrogen receptor activity, thereby reducing gynecomastia linked with steroid use. Additionally, by blocking brain estrogen receptors, Clomid prompts the hypothalamus to release more LH and FSH, promoting testosterone synthesis, providing an extra competitive edge for athletes. Bodybuilders may use Clomid solely for its anabolic effects or along with a combination of other steroids and growth hormones.

Clomid-dosering til atleter

Clomid is generally taken once daily. Bodybuilding experts suggest using it alone or with low-potency anabolic steroids. Many bodybuilders rotate between anabolic steroids for a few months, introducing Clomid afterward to stimulate testosterone levels and prevent breast enlargement. The optimal timing to commence Clomid is not precisely defined, but it should ideally begin within 7-10 days post-steroid cessation.

A considerable number of athletes and bodybuilders use Clomid, but dosage varies widely. While not officially recommended in bodybuilding, empirical dosing suggests 50-100 mg/day for a two-week period. If no results are observed, some bodybuilders advise increasing the dosage to 100 mg/day. Clomid administration typically ends after three weeks. This cycling approach developed by previous bodybuilders is often unadvised by medical professionals, making it challenging to acquire reliable guidance regarding this medication. Seeking advice from fertility specialists knowledgeable about Clomid is advisable for those uncertain about its use.

The exact duration of Clomid usage remains unclear, with a general consensus advocating against prolonged use.

Bivirkninger

At recommended dosages and for short durations, Clomid is considered safe, with most side effects being transient and resolving upon treatment cessation.

Common side effects include:

• Flushing
• Abdominal discomfort
• Nausea, vomiting
• Breast tenderness
• Headaches
• Abnormal vaginal bleeding
• General fatigue
• Hårtab
• Visual symptoms

Notably, Clomid influences the brain, raising concerns about one serious side effect. By blocking estrogen receptors in the hypothalamus, it leads to increased stimulation of the pituitary gland, which can cause it to enlarge and compress optic nerves, potentially resulting in visual disturbances. Reports suggest changes may arise even after short-term use and may impact driving and machinery operation. Most vision changes diminish once Clomid is discontinued, and a visit to an ophthalmologist is strongly advised if such symptoms occur.

Mood Changes

Mood alterations are another notable side effect. Women using Clomid long-term report a range of behavioral issues, including severe depression, anger, anxiety, and aggression, along with restlessness and insomnia. Despite the alarming nature of these effects, clinical trials indicate that they emerge in less than 1% of women, with insufficient data on bodybuilders’ experiences.

Omkostninger

Although Clomid requires a physician’s prescription for infertility treatment, it is readily available online without one. Prices vary; on average, 100 pills (25-50 mg) range from $50-100.

Niveauer

Clomiphene is easily accessible for anyone. However, all major sports organizations prohibit its use in professional competitions. It can be detected in urine for 5-12 days post-use, with sophisticated testing identifying levels of testosterone and estrogen, as well as their metabolites. A particular ratio might signal Clomid abuse.