Sunrise Malegra DXT 10 tabs (100 + 30 mg/tab)

Sildenafil

Viagra is a well-known medication classified as a phosphodiesterase type 5 (PDE5) inhibitor, primarily used for addressing erectile dysfunction.

Mechanism of Action

• Sildenafil inhibits the enzyme phosphodiesterase type 5 (PDE5), leading to increased levels of cyclic guanosine monophosphate (cGMP). This promotes greater blood flow to the penis during sexual stimulation by relaxing smooth muscle in blood vessels.
• This process facilitates achieving and sustaining an erection.

Ενδείξεις

• Primarily indicated for treating Erectile Dysfunction in men.
• Also utilized in managing pulmonary arterial hypertension as Revatio.

Onset of Action

• Typically begins working within 30 minutes, although effects may take up to an hour for some individuals.

Duration of Action

• Lasts approximately 4 to 5 hours, enabling the maintenance of an erection throughout this period.

Δοσολογία

• Commonly initiated at a dose of 50 mg, adjustable based on individual response and tolerance.
• Recommended to take it 30 minutes to 1 hour prior to anticipated sexual activity.

Παρενέργειες

• Potential side effects include headache, facial flushing, dyspepsia, visual disturbances, increased blood pressure, and rare cases of hearing changes.

Αντενδείξεις

• Should not be taken alongside nitrates due to the risk of severe hypotension; contraindicated in patients with significant cardiovascular issues or recent heart attacks or strokes.

Duloxetine

Cymbalta is classified as a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) used primarily for mood and pain disorders.

Mechanism of Action

• Enhances serotonin and norepinephrine levels in the brain, aiding mood improvement and pain perception reduction.

Ενδείξεις

• Effectively treats depressive disorders.
• Approved for Generalized Anxiety Disorder (GAD).
• Used for neuropathic pain related to diabetic peripheral neuropathy and fibromyalgia.
• Managed chronic pain in individuals with persistent back issues.

Onset of Action

• May require several weeks for full effect in depression treatment; faster relief may occur for anxiety and pain.

Δοσολογία

• Typically introduced at lower doses and gradually increased based on patient response; common dosage for depression is 40 to 60 mg daily.
• For pain management associated with diabetic peripheral neuropathy or fibromyalgia, a higher dosage of 60 mg daily is common.

Παρενέργειες

• Possible side effects include hot flashes, dry mouth, gastrointestinal issues, sleep disturbances, loss of appetite, headaches, increased anxiety, and sexual dysfunction.

Αντενδείξεις

• Not recommended for individuals with specific liver conditions or those using monoamine oxidase inhibitors (MAOIs); pregnant women should exercise caution, particularly in the late stages of pregnancy.