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Sildenafil

Medication known by its trade name Viagra belongs to the class of drugs termed PDE5 Inhibitors.

Explore the essential attributes of Sildenafil.

Mechanism of Action

• Sildenafil inhibits the enzyme PDE5, preventing the breakdown of cyclic guanosine monophosphate (cGMP). This process augments blood flow to the penis during sexual arousal by relaxing smooth muscle in the blood vessels.
• This mechanism facilitates the achievement and maintenance of an erection.

Indications

• Sildenafil is primarily utilized to address Erectile Dysfunction in males.
• Additionally, it may be prescribed under the name Revatio for treating arterial hypertension.

Onset of Action

• The onset of action for Sildenafil typically occurs within 30 minutes, although it can take up to 1 hour for some individuals.

Duration of Action

• The effectiveness of Sildenafil lasts approximately 4 to 5 hours, supporting the process of achieving and sustaining an erection.

Dosage

• The standard initial dosage of Sildenafil is 50 mg, which can be adjusted based on individual responses.
• The dosage should be taken around 30 minutes to 1 hour before anticipated sexual activity.

Side Effects

• Common side effects can include headache, facial flushing, indigestion (e.g., nausea, diarrhea), visual disturbances (e.g., blurred vision, changes in color perception), elevated blood pressure, and in rare cases, hearing loss or changes in auditory perception.

Contraindications

• Sildenafil should not be taken alongside nitrates (e.g., nitroglycerin) due to the risk of a severe drop in blood pressure.
• It is contraindicated for individuals with significant cardiovascular issues, recent heart attacks, or strokes.