Hubei Clomid 30 tabs (50 mg/tab)

Clomiphene Citrate – Clomid

Clomiphene citrate, known as Clomid, is a synthetic, non-steroidal medication closely resembling estrogen in structure. It effectively serves as an ovulatory stimulant by binding to estrogen receptors in the hypothalamus, preventing it from detecting actual estrogen levels. This triggers the pituitary gland to increase the release of Gonadotropins like FSH and LH, which in turn stimulate the ovaries or testes to elevate estrogen or testosterone production.

This unique capability of clomiphene citrate is essential in treating women with ovarian issues and inducing ovulation. However, prolonged use raises concerns about the potential risk of ovarian cancer.

Pharmacology

Clomid is primarily prescribed for women with ovulatory dysfunction. Many women struggling with infertility find that ovulation disorders, such as polycystic ovarian syndrome or unknown amenorrhea causes, contribute to their challenges. A comprehensive evaluation of the menstrual cycle is crucial before prescribing Clomid. The timing of administration, typically beginning around the 5th day of the menstrual cycle for a duration of 3-6 cycles, is vital for successful ovulation induction.

Mode of Action

Clomid’s potent action aids infertile women when prescribed correctly over a short duration. By mimicking estrogen’s effects, it blocks receptors in the hypothalamus, tricking the brain into sensing low estrone levels. This stimulates a surge of Gonadotropins, enhancing ovarian estrogen production and steroid synthesis, which is critical for fertilization.

Indications

Clomid is advised for women experiencing ovulatory dysfunction, who meet the following criteria:

• Non-pregnant status
• No presence of ovarian cysts, confirmed via ultrasound
• Absence of vaginal bleeding, necessitating examination for potential cancer
• Normal liver function tests
• While Clomid shows promise for female infertility, studies in male infertility remain limited; benefits observed include increased LH and FSH levels with a resulting boost in sperm count. Caution exists regarding potential long-term effects like testicular tumors and gynecomastia.
• Prescription dosage for infertility management

Clomiphene, an odorless large molecule, is soluble in most organic solvents, including alcohol, and is available as a 50 mg tablet.

Prior to Clomid administration, patients must undergo a thorough examination for all gynecological and endocrine issues. Ovulation typically occurs 5-10 days post-initiation. Timing of intercourse around the expected ovulation date is crucial for optimizing chances of conception.

Initial treatment starts at 50 mg/day for 5 days, with adjustments made for women who do not ovulate.

Bodybuilding

Clomid is frequently misused by both amateur and professional athletes alongside other substances like anabolic steroids, HCG, and tamoxifen. Unlike typical steroids that may suppress testosterone, Clomid increases it by triggering LH surges.

Anabolic steroids often possess both androgenic and anabolic properties, with some exhibiting mild estrogen-like activity. As anabolic steroids can convert to estrogen in fatty tissues through aromatization, they can lead to gynecomastia. Clomid, by blocking estrogen receptors, helps prevent this side effect.

Furthermore, Clomid’s inhibition of brain estrogen receptors stimulates the hypothalamus, leading to increased synthesis of sex hormones. While some bodybuilders use Clomid solely for its tangible anabolic effects, others combine it with various steroids and growth hormones.

Clomid Dosage for Athletes

Clomid usage is limited to once daily, typically in conjunction with low potency anabolic steroids or following steroid cycles. Bodybuilders often transition to Clomid after several months of steroid use to ensure a surge in testosterone and to combat any breast enlargement. Starting Clomid within 7-10 days post-steroid cessation is generally recommended.

The dosage among athletes varies significantly but typically ranges between 50-100 mg/day for a two-week period, with some suggesting to escalate to 100 mg/day if results are insufficient. After three weeks, discontinuation of Clomid is advised based on prior bodybuilding experiences. Given the lack of medical endorsement for its use in bodybuilding, consult with fertility experts for guidance on this medication.

The long-term effects of Clomid remain understudied; extended usage should be avoided.

Side Effects

When taking Clomid at recommended short-term doses, it is generally safe, and side effects usually dissipate after treatment cessation.

Common adverse effects include:

• Flushing
• Abdominal discomfort
• Nausea and vomiting
• Breast tenderness
• Headaches
• Abnormal vaginal bleeding
• General fatigue
• Hair loss
• Visual disturbances

Due to its action on the brain, significant visual side effects may arise, stemming from pituitary gland swelling that compresses optic nerves, leading to blurry vision or other visual changes, even after short-term use. Discontinuation of Clomid is essential upon experiencing these issues, and ophthalmological evaluation is highly recommended.

Mood Changes

Another notable side effect involves mood alterations. Some women report behavioral changes such as severe depression, anger, anxiety, and aggression when on Clomid for extended periods. Other reported changes include paranoia, restlessness, and insomnia.

Despite these concerns, clinical studies indicate that severe side effects affect less than 1% of women; data on bodybuilding participants remain limited.

Cost

Although a physician’s prescription is necessary for infertility treatment, Clomid is easily accessible online without a prescription. Costs vary, with an average of $50-100 for 100 pills (25-50 mg).

Levels

Clomiphene’s availability is widespread, though all major sports organizations have prohibited its use. Detection methods for Clomid in urine post-use extend from 5 to 12 days, with some laboratories able to measure hormone levels and metabolites to assess potential abuse.