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Sildenafiil

Sildenafiil is a prominent medication categorized under phosphodiesterase type 5 (PDE5) inhibitors, widely recognized by the brand name Viagra.

Sildenafiil is characterized by its:

Mechanism of Action

• Sildenafiil inhibits the phosphodiesterase type 5 (PDE5) enzyme, leading to increased levels of cyclic guanosine monophosphate (cGMP).
• This action enhances nitric oxide (NO) release during sexual arousal, promoting smooth muscle relaxation and higher blood flow to the penis, enabling an erection.

Näidustused

• Primarily prescribed for treating erectile dysfunction in men.
• Also utilized for managing pulmonary arterial hypertension under the name Revatio.

Onset of Action

• Typically, Sildenafiil begins to work within 30 minutes, but effects may take up to 1 hour in some users.

Duration of Action

• Its effects last between 4 to 5 hours, sufficient for achieving and maintaining an erection.

Annustamine

• Initial recommended dose is 50 mg, adjustable based on individual response and requirements.
• It’s advisable to take the dosage roughly 30 minutes to 1 hour prior to sexual activity.

Kõrvaltoimed

• Common adverse effects may include headache, facial flushing, indigestion (nausea, diarrhea), vision alterations (blurred vision, color changes), elevated blood pressure, and rarely, hearing impairments.

Vastunäidustused

• Should not be combined with nitrates (e.g., nitroglycerin) due to risks of severe hypotension.
• Contraindicated in individuals with significant heart issues or a recent history of myocardial infarction or stroke.