Euro-Pharmacies T3+T4 20 tabs (30 + 120 mcg/tab)

Liothyronine – Cytomel

Thyroid hormones, integral to our body’s metabolism, can be synthesized synthetically by pharmaceutical companies due to their relatively simple molecular structure. The two primary types of these hormones are T4 (levothyroxine) and T3 (liothyronine), both of which are produced and stored in the thyroid gland.

Pharmaceutical thyroid hormones are derived in two methods: from animal thyroid glands (bovine or ovine) or fabricated synthetically. In the USA, thyroid preparations’ iodine content is meticulously regulated.

Cytomel (liothyronine sodium) is offered in tablet form and represents a naturally occurring thyroid hormone salt. Notably, T3 is significantly more potent than T4.

Farmakoloogia

The exact mechanisms of thyroid hormone actions remain unclear, but they initiate numerous biochemical processes within cells, providing essential energy. These hormones elevate the metabolic rate by promoting the utilization of carbohydrates, lipids, and proteins, alongside increasing oxygen consumption. Their influence extends across nearly all organs, including the brain, emphasizing their critical role especially when assessing hormone deficiency in patients.

Annustamine

Thyroid hormone exhibits swift absorption from the gastrointestinal tract into the bloodstream, with effects emerging within hours, while peak activity may take several days. Its presence in the body can last for a few days post-administration due to strong binding with albumin, which aids in its protection from metabolic breakdown.

Common indications for thyroid hormone therapy include:

• Replacement therapy for individuals with hypothyroidism
• Post-surgical replacement in patients with removed thyroid
• Management of goiters and thyroid nodules
• Diagnostic use in suppression tests to differentiate conditions like hyperthyroidism
• Providing alternatives for patients allergic to animal-sourced thyroid hormones, allowing use of Cytomel.

Kehaehitajad ja kaalulangus

Both amateur and professional athletes have used thyroid hormone, particularly Cytomel, as a weight loss aid for decades due to its ability to accelerate fat and carbohydrate combustion. Its optimal administration lasts 4-6 weeks, deliberately stopped just before competitions to maximize impact. Athletes consistently report weight loss and enhanced energy with short-term Cytomel usage.

However, complex interactions arise due to concurrent use of multiple supplements and hormones. Recommendations for weight management often suggest initiating Cytomel at 25 ug/day, increasing incrementally every few weeks, with maximum safe doses reaching around 100 ug/day. Users must taper off to mitigate induced thyroid insufficiency.

Märgid ja sümptomid

Hyperthyroid symptoms may manifest as:

• Headaches
• Mood changes—irritability, anxiety
• Excessive sweating
• Irregular heart rhythms
• Palpitatsioonid
• Valu rinnus
• Kõhulahtisus
• Menstruatsioonihäired
• Potential worsening of heart failure
• Šokk

Overdosage may lead to a severe condition known as thyroid storm, while chronic excess may simulate hyperthyroid symptoms.

Vastunäidustused

Thyroid hormone is contraindicated in those with untreated adrenal insufficiency, active thyrotoxicosis, or known hypersensitivity. True allergic reactions to liothyronine are rare, though caution is advised.

Tasandid

Thyroid hormone levels can be readily assessed. Sports authorities, including the IOC and WADA, routinely monitor athletes for these hormones, utilizing sensitive radioimmunoassays capable of detecting minimal amounts in urine.

Ravimite koostoimed

Liothyronine may interact with various medications, such as:

• Oral anticoagulants
• Insulin or oral hypoglycemics
• Cholestyramine
• Estrogens, including oral contraceptives
• Tricyclic antidepressants
• Digitalis

It is imperative that physicians oversee dosages to prevent excess, with regular follow-ups for all thyroid hormone patients.

Üleannustamise ravi

Suspected thyroid hormone overdose requires hospitalization. Treatment involves halting the hormone, monitoring, and allowing for thyroid recovery, typically needing 4-8 weeks. Supportive care is key, without inducing vomiting owing to aspiration risks. Severe cases might warrant beta-adrenergic blockers to alleviate sympathetic overactivity.

Annustamine

Liothyronine is administered as a daily tablet. Dosages are tailored based on hypothyroidism severity, initiating therapy with the lowest effective dose considering its fast-acting nature. The starting dose for Cytomel is 5 mcg/day, adjustable upwards in small increments at intervals of 2-3 weeks to avoid exacerbating heart issues. Generally, doses range between 50-75 ug/day for most patients. Liothyronine can also be given intravenously for critical conditions, such as myxedema coma, a severe complication of hypothyroidism mostly affecting elderly women.

Liothyronine is available in 5, 25, and 50 ug tablets, requiring a doctor’s prescription in the USA.

T4 – Liothyronine sodium

A synthetic thyroid hormone, levothyroxine is primarily utilized for treating hypothyroidism, mimicking T4 hormones produced by the thyroid. T4 notably influences central nervous system function, fat metabolism, cellular health, and overall well-being.

Annustamine

100 – 300 mcg per day.

Efektid

Utilizing T4 allows athletes to enhance performance and achieve weight loss without increased hunger.

Kõrvaltoimed

Common adverse effects of T4 include insomnia, trembling, anxiety, irregular heartbeat, and suppression of natural thyroid hormone production.

Kaitse

To minimize side effects, integrating beta-adrenoblockers and ketotifen during the cycle is advised. Administering T4 in the morning can help avoid sleep disturbances.

Virnastamine

Extra caution is essential when combining T4 with other medications that influence blood pressure and heart rate.