Novo Nordisk Norditropin Simplexx 1 vial (1x 45 IU)

HGH – Human Growth Hormone

Human growth hormone, or GH, is a vital substance secreted by the anterior pituitary gland, playing a crucial role in growth and development. Its levels peak during late adolescence but decline as we age, particularly after the age of 40. Over the past four decades, GH has been utilized for treating specific medical conditions, yet recent trends show a surge in its popularity among individuals seeking anti-aging effects, enhanced physical appearance, and improved athletic performance. Among athletes, GH is one of the top substances abused.

What is Human Growth Hormone?

Human growth hormone, commonly referred to as hGH, is crucial for cellular growth and metabolic regulation. Produced by the anterior pituitary, it works in concert with other hormones to promote proper development. GH levels peak at puberty and significantly decrease by age 40. Growth hormone can be easily sourced through health food stores, spas, and various practitioners, often found under different brand names like Genotropin®, Humatrope®, Norditropin®, Nutropin®, Saizen®, and Serostim®.

Farmakoloogia

Most GH on the market is synthesized using recombinant DNA technology, with somatropin and somatrem being the primary forms. Both types perform similarly, indistinguishable from naturally occurring GH once injected. GH is pivotal in metabolism regulation, maintaining electrolyte balance, and increasing muscle and skeletal mass, with levels rising during sleep, stress, and exercise.

Conditions Affecting GH Levels

Imbalances in GH levels can lead to serious medical conditions. Excessive GH can cause acromegaly, marked by enlarged extremities and ongoing cell growth, or pituitary gigantism, resulting in extreme height. Conversely, GH deficiency can lead to significant health issues, including short stature.

FDA Approved Uses of GH

The FDA has sanctioned several GH injections for specific medical conditions, only available with a prescription. Initially approved in 1985 for GT deficiency, GH has since been recognized for treating disorders like Prader-Willi syndrome, cannabinoid-induced short stature, Turner syndrome, and conditions linked to pituitary tumors. Recent approvals also allow GH to aid adults experiencing AIDS-related wasting syndrome. Clinical studies substantiate the benefits of GH in these disorders, showcasing:

• Increased Muscle Mass
• Decreased Body Fat
• Improved Mentation
• Enhanced Exercise Performance
• Increased Cardiovascular Tolerance

Annustamine

GH is administered exclusively through injections—subcutaneous or intramuscular. Its notable effects kick in rapidly upon entering the bloodstream. The appropriate dosage is still debated, although recent research emphasizes adjusting based on IGF levels. For adults, dosages typically range from 0.01-0.1 mg/kg, depending on the intended purpose and product form.

Potential Side Effects of GH

GH usage may lead to several adverse effects, including:

• Generalized Edema
• Carpal Tunnel Syndrome
• Joint and Muscle Pain
• Neuropathies (e.g., numbness and tingling)
• Increased Blood Glucose Levels

Prescription Requirements for GH

GH is restricted to FDA-approved indications, although off-label uses, including athletic enhancement and anti-aging, are prevalent. The FDA has not endorsed these uses due to the risk-benefit ratio. Prospective users should heed the potential side effects associated with GH therapy.

Risks of GH Usage

Overdosing on GH risks an array of severe conditions, such as acromegaly and the potential activation of unwanted cell growth, including cancer. Additionally, less severe side effects can manifest as fluid retention, carpal tunnel syndrome, joint discomfort, and increased diabetes risk. Individuals contemplating GH for anti-aging must evaluate the therapy’s drawbacks.

Off-Label Applications

Bodybuilding GH is extensively misused for bodybuilding and anti-aging, ranking among athletes’ most abused substances. Though accessible, possessing GH is illegal. Many bodybuilders combine it with various drugs, complicating the identification of effective substances. GH’s challenging detection contributes to its popularity among athletes. GH prices range widely, from $500 to $2000 per month, with risks of counterfeit products.

Anti-Aging

Despite widespread beliefs in its anti-aging properties, GH lacks FDA approval for this use and evidence supporting its effectiveness in reversing wrinkles or altering skin texture. The growth in anti-aging GH treatments has spurred a $70 million industry, with patients often spending $10,000 to $20,000 annually on authentic GH at medical facilities.

Kättesaadavus

Most individuals acquire GH through illegal means, whether stolen from pharmacies, obtained via unscrupulous prescriptions, or smuggled from other countries. Online pharmacies often distribute GH without legitimate medical oversight, with many selling GH’s less effective forms, such as sprays or topical gels, which the body absorbs poorly.

Testing Limitations

Detecting synthetic GH is notably difficult, with current testing methods failing to trace it beyond 48 hours post-injection, a fact well-known among athletes.

Sermorelin

Sermorelin is a newer drug impersonating the original Geref, a GHRH analog stimulating GH production. It eludes detection in blood and urine for significant periods, leaving current regulations in place. Sermorelin has a gradual onset, requiring three to four weeks for noticeable effects, making it less effective for individuals lacking GH and costing $300 to $1000 monthly.

Kontrolli staatus

In response to the widespread misuse of GH, federal regulations limit its sales and distribution. Possession or distribution poses legal risks, with penalties that may include jail time and fines. The 2007 Senate bill proposed amending the Controlled Substances Act to classify GH as a Schedule III substance. Moreover, GH is recognized as a performance-enhancing substance by the World Anti-Doping Agency and the International Olympic Committee, rendering it illegal for athletes.