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Tadalafil - Cialis

Tadalafil is a potent medication classified as a phosphodiesterase type 5 (PDE5) inhibitor. It is commonly known by its brand names, Cialis for erectile dysfunction and Adcirca for pulmonary arterial hypertension.

Discover the key attributes of Tadalafil:

Mechanism of Action

• Tadalafil inhibits the enzyme PDE5, preventing the breakdown of cyclic guanosine monophosphate (cGMP).
• Upon sexual stimulation, nitric oxide (NO) release enhances cGMP levels.
• This process relaxes smooth muscles in blood vessels, increasing penile blood flow and facilitating erection.

Indications

• Tadalafil is primarily prescribed for treating erectile dysfunction in men.
• It’s also utilized in managing benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension as Adcirca.

Onset of Action

• The onset of effect is typically rapid, occurring within 30 minutes to 1 hour of ingestion.

Duration of Action

• Effects can last up to 36 hours, earning it the nickname “weekend pill.”
• This allows men to achieve erections throughout this duration with sexual stimulation.

Dosage

• For erectile dysfunction, the typical dose ranges from 10 mg to 20 mg, taken 30 minutes before sexual activity.
• For BPH, a daily dosage of 5 mg is recommended.

Effets secondaires

• Common adverse effects may include headache, facial flushing, dyspepsia, dizziness, muscle aches, and back pain.
• Rare, but serious side effects such as sudden vision or hearing loss are also possible.

Contre-indications

• Avoid combining Tadalafil with nitrates (e.g., nitroglycerin) to prevent severe hypotension.
• Not suitable for patients with significant heart issues or recent myocardial infarction or stroke.