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Sildénafil

Viagra is a renowned medication classified as a phosphodiesterase type 5 (PDE5) inhibitor, effectively treating various conditions related to erectile dysfunction.

Mechanism of Action

• By inhibiting the enzyme phosphodiesterase type 5 (PDE5), Sildénafil prevents the breakdown of cyclic guanosine monophosphate (cGMP), leading to enhanced blood flow to the penis during sexual arousal.
• This process enables the user to achieve and sustain an erection.

Indications

• Sildenafil is primarily indicated for treating erectile dysfunction in men.
• Additionally, it is utilized in managing arterial hypertension under the name Revatio.

Onset of Action

• This medication typically begins to exert its effects within 30 minutes, although some individuals may experience onset up to 1 hour.

Duration of Action

• The effects of Sildénafil last between 4 to 5 hours, ensuring adequate time for an erection to be achieved and maintained.

Dosage

• The recommended starting dose of Sildénafil is 50 mg, which can be adjusted based on individual needs.
• It should be taken approximately 30 minutes to 1 hour prior to planned sexual activity.

Effets secondaires

• Common side effects include headache, facial flushing, indigestion, vision alterations, elevated blood pressure, and, in rare cases, hearing loss.

Contre-indications

• Usage of Sildénafil with nitrates (e.g., nitroglycerin) is prohibited due to the risk of severe blood pressure drops, and it is contraindicated in patients with significant heart issues or a recent history of myocardial infarction or stroke.