Ajanta Tadalis-SX 4 tabs (20 mg/tab)

Tadalafil - Cialis

Tadalafil, a member of the phosphodiesterase type 5 (PDE5) inhibitors, is widely recognized under the brand names Cialis for erectile dysfunction and Adcirca for pulmonary arterial hypertension.

Mechanism of Action

• Tadalafil inhibits the enzyme phosphodiesterase type 5 (PDE5), which is responsible for the breakdown of cyclic guanosine monophosphate (cGMP).
• Upon sexual stimulation, nitric oxide (NO) promotes higher levels of cGMP, leading to enhanced blood flow.
• This increased blood flow relaxes smooth muscle in the blood vessels, facilitating the erection process.

Indications

• This medication is primarily indicated for the treatment of erectile dysfunction in men.
• It is also effective for managing benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension as Adcirca.

Onset of Action

• Tadalafil typically takes effect within 30 minutes to 1 hour following administration.

Duration of Action

• The therapeutic effects of tadalafil can persist for up to 36 hours, often termed the “weekend pill.”
• This allows for sustained erectile ability during this time frame with proper stimulation.

Dosage

• For erectile dysfunction, the recommended dosage is typically 10 mg or 20 mg, taken around 30 minutes prior to sexual activity.
• For BPH, a daily dosage of 5 mg is standard.

Effets secondaires

• Common side effects may encompass headaches, facial flushing, digestive issues (nausea, diarrhea), dizziness, muscle aches, and back pain.
• Serious concerns, although rare, may include sudden vision or hearing loss.

Contre-indications

• Tadalafil must not be combined with nitrates (such as nitroglycerin) due to the risk of severe hypotension.
• It is contraindicated in individuals with significant heart conditions or those who experienced a recent myocardial infarction or stroke.