Euro-Pharmacies T3 20 tabs (50 mcg/tab)

Liothyronine - Cytomel

The human body naturally produces thyroid hormones, yet many pharmaceutical firms offer synthetic alternatives. The primary types of thyroid hormones are T4 (levothyroxine) and T3 (liothyronine), both synthesized and stored within the thyroid gland.

Pharmaceutical thyroid hormones are sourced primarily in two ways: derived from animal thyroid glands (bovine or ovine) or synthetically manufactured. In the United States, the iodine content in thyroid preparations is strictly regulated.

Cytomel (liothyronine sodium) is accessible in both tablet form and as the salt of a naturally occurring thyroid hormone. Notably, T3 is significantly more potent than T4.

Farmacologia

The exact mechanisms by which thyroid hormones operate remain unclear, but they initiate various biochemical changes within cells. These hormones primarily boost energy levels, enhancing the metabolic consumption of carbohydrates, lipids, and proteins while increasing oxygen utilization. Users often exhibit a heightened basal metabolic rate. The influence of these hormones extends to nearly every organ, including the brain, underscoring their significance, particularly in patients lacking adequate hormone levels.

Dosaggio

Thyroid hormone is promptly absorbed into the bloodstream from the stomach, with effects manifesting within hours. Maximum activity may take several days, and the hormone can persist in the body for days, binding to albumin to inhibit liver breakdown.

Indicazioni per l'ormone tiroideo:

• Replacement therapy for patients with hypothyroidism
• Replacement therapy post-thyroidectomy
• Management of goiters and thyroid nodules
• Diagnostic agents in suppression tests to differentiate suspected hyperthyroidism from thyroid gland autonomy
• For patients allergic to pork or beef thyroid, Cytomel can serve as a suitable alternative

Body Builders e perdita di peso

For years, athletes—both amateur and professional—have exploited thyroid hormones for weight loss. By boosting fat and carbohydrate combustion, many have turned to Cytomel for performance enhancement in various sports. Administered orally for a span of 4 to 6 weeks, with cessation one week before competitive events, Cytomel acts as an efficient fat-burning agent and energy booster. Athletes often note significant weight loss and increased vitality following short-term use.

Nonetheless, complexities arise as many athletes combine Cytomel with a variety of other supplements. Online vendors commonly recommend a starting dose of 25 ug/day, gradually increasing by 5-10 ug/day over a few weeks, with a maximum of approximately 100 ug/day to avoid adverse effects. Evidence from athletes indicates that weight loss via Cytomel may take 6 to 12 weeks. Crucially, users must recognize that stopping Cytomel can lead to thyroid insufficiency as it suppresses natural hormone production. Dosage should therefore be gradually reduced over weeks to months, allowing the thyroid gland to resume normal function. Consultation with a physician is highly recommended for those considering off-label use for weight loss.

Segni e sintomi

Excess intake of thyroid hormone may result in side effects including:

• Mal di testa
• Mood changes—irritability, nervousness, anxiety
• Increased sweating
• Ritmi cardiaci anomali
• Palpitazioni
• Dolore al petto
• Diarrea
• Irregolarità mestruali
• Exacerbation of heart failure
• Scossa

High dosages may mimic a thyroid storm, whereas chronic overuse leads to symptoms of hyperthyroidism.

Controindicazioni

Thyroid hormones are contraindicated for those with untreated adrenal cortical insufficiency, untreated thyrotoxicosis, or hypersensitivity to any components. Genuine allergic reactions to liothyronine are exceedingly rare.

Livelli

Thyroid hormone levels can be readily monitored, with sporting agencies such as the IOC and WADA routinely testing athletes for these hormones. The available radioimmunoassays detect even minimal quantities of the hormone in urine.

Interazioni con i farmaci

Liothyronine may interact with multiple medications, including:

• Oral anticoagulants
• Insulin or oral hypoglycemics
• Cholestyramine
• Estrogen, oral contraceptives
• Tricyclic antidepressants
• Digitalis

In all instances, physicians must ensure thyroid hormone dosages remain within safe limits. Regular monitoring is essential for patients using thyroid hormones.

Trattamento del sovradosaggio

If thyroid hormone overdose is suspected, hospital admission is critical. Discontinue the hormone, observe, and monitor the patient. Most individuals require a cessation period of 4 to 8 weeks for recovery. No specific antidotes exist for thyroid overdose, necessitating supportive care only. Induction of vomiting is contraindicated due to aspiration risks. In cases of coma, mechanical ventilation might be necessary. Typically, fluids, oxygen, and observation are sufficient, although beta-adrenergic blockers may be deployed to mitigate sympathetic effects.

Dosaggio

Liothyronine is available in tablet form, ideally taken once daily. Dosage varies based on hypothyroidism severity. Initiate therapy with the lowest effective dose, as the onset is relatively rapid. Starting with 5 mcg/day and increasing by no more than 5 mcg/day at 2 to 3-week intervals is recommended. High initial doses or abrupt increases can exacerbate preexisting cardiac conditions. Most patients benefit from doses between 50-75 ug/day. Liothyronine is also offered in intravenous form for severe cases like myxedema coma, a critical complication of hypothyroidism primarily affecting elderly women. Prescription is mandatory for liothyronine in the USA.