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Sildenafil

Sildenafil, marketed under the trade name Viagra, is a renowned medication categorized as a phosphodiesterase type 5 (PDE5) inhibitor. Its key characteristics are outlined below.

Meccanismo d'azione

• This medication inhibits phosphodiesterase type 5 (PDE5), leading to an increase in cyclic guanosine monophosphate (cGMP) levels during sexual stimulation. The release of nitric oxide (NO) in penile tissues results in muscle relaxation of blood vessels, enhancing blood flow to the penis.
• This mechanism facilitates the achievement and maintenance of an erection.

Indicazioni

• Sildenafil is primarily indicated for the treatment of erectile dysfunction in men.
• It is also utilized for treating arterial hypertension under the name Revatio.

Inizio dell'azione

• The onset of Sildenafil typically occurs around 30 minutes post-consumption, although it may take up to 1 hour for some individuals.

Durata dell'azione

• The effects of Sildenafil generally last between 4 to 5 hours, sufficient for achieving and sustaining an erection.

Dosaggio

• The standard initial dose is 50 mg, adjustable based on individual efficacy and tolerance.
• Dosing should occur approximately 30 minutes to 1 hour prior to anticipated sexual activity.

Effetti collaterali

• Commonly reported side effects include headache, facial flushing, indigestion (such as nausea and diarrhea), vision alterations (including blurred and color vision changes), elevated blood pressure, and, though rare, hearing loss or changes.

Controindicazioni

• Sildenafil is contraindicated in conjunction with nitrates (e.g., nitroglycerin) due to the risk of severe blood pressure drop. It should also be avoided in individuals with severe heart conditions, recent myocardial infarction, or stroke.