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Sildenafil

Sildenafil, commonly known as Viagra, is a member of the phosphodiesterase type 5 (PDE5) inhibitor class of medications.

Explore the key aspects of Sildenafil:

Mechanism of Action

• Sildenafil blocks the enzyme PDE5, which typically deactivates cyclic guanosine monophosphate (cGMP). The release of nitric oxide (NO) during sexual arousal boosts cGMP, leading to relaxation of the smooth muscle and enhanced blood flow to the penis.
• This promotes the achievement and maintenance of an erection.

Indicazioni

• Sildenafil is primarily indicated for treating erectile dysfunction in men.
• Additionally, it is utilized in managing arterial hypertension under the brand name Revatio.

Onset of Action

• The onset of Sildenafil is typically rapid, with effects noticeable within 30 minutes, though it may take up to 1 hour for some individuals.

Duration of Action

• The action of Sildenafil generally lasts for 4 to 5 hours, sufficient for sustaining an erection.

Dosaggio

• The standard starting dose for Sildenafil is 50 mg, adjustable based on individual response.
• This dose is recommended approximately 30 minutes to 1 hour before sexual activity.

Effetti collaterali

• Common side effects include headache, facial flushing, indigestion, vision changes (such as blurred vision and color perception alterations), increased blood pressure, and, albeit rarely, hearing loss or changes.

Controindicazioni

• Use of Sildenafil alongside nitrates (like nitroglycerin) is contraindicated due to the risk of a significant drop in blood pressure. It is also not recommended for individuals with severe cardiovascular issues, recent heart attack, or stroke.