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Nandrolons fenilpropionāts

Nandrolone phenylpropionate is an injectable anabolic steroid closely resembling Deca-Durabolin, which incorporates the slower-acting nandrolone decanoate. The key distinction lies in the release speed; while nandrolone decanoate sustains release for about three weeks post-injection, nandrolone phenylpropionate remains active for just one week. In clinical scenarios, Deca-Durabolin may be administered biweekly, while Durabolin is typically injected several times a week. Both steroids serve interchangeably, as athletes and bodybuilders favor Deca-Durabolin for boosting strength and enhancing lean muscle mass with minimal estrogenic and androgenic side effects.

Strukturālie raksturlielumi

Nandrolone phenylpropionate features a modified form of nandrolone, with a propionic phenyl ester attached to its 17-beta hydroxyl group. Esterified steroids are less polar and are absorbed more slowly at the injection site. Following administration, the ester is removed, yielding free nandrolone. This design extends the effects of the drug, permitting infrequent injections compared to unesterified steroids. After a deep IM injection, nandrolone phenylpropionate triggers a rapid spike in nandrolone within 24-48 hours, tapering off to baseline levels within a week.

Blakusparādības (estrogēnu)

With a low tendency for estrogen conversion at about 20% of testosterone, nandrolone’s estrogen-related side effects are less concerning. While some effects like water retention and gynecomastia may occur at high doses, they can often be managed with anti-estrogens such as clomiphene citrate or tamoxifen citrate. Aromatase inhibitors like Arimidex (anastrozole) may also effectively regulate estrogen but can be pricier and affect blood lipid levels. Notably, nandrolone exhibits progestin-like activity, potentially causing side effects akin to estrogen, including testosterone production inhibition and increased fat storage. Gynecomastia risks can emerge from nandrolone without elevated estrogen, requiring anti-estrogen intervention.

Blakusparādības (androgēnas)

Despite being primarily an anabolic steroid, nandrolone may induce androgenic side effects, especially at high doses, resulting in oily skin, acne, and excessive body or facial hair growth. For women, virilization symptoms can occur, such as voice deepening and menstrual irregularities. Nandrolone’s lower androgenic activity compared to testosterone provides a higher threshold for adverse effects. However, it can still suppress libido due to its interaction with testosterone. In androgen-sensitive tissues like the scalp and prostate, nandrolone’s androgenic potential is moderated through conversion to dihydronandrolone (DHN). Caution should be taken with 5-alpha reductase inhibitors like finasteride, which may exacerbate androgenic side effects when used concurrently.

Blakusparādības (hepatotoksicitāte)

Since nandrolone is not c-17 alpha alkylated, it is not associated with hepatic toxicity risks in healthy individuals, making liver damage unlikely.

Blakusparādības (sirds un asinsvadu sistēmas)

Anabolic and androgenic steroids can adversely affect serum cholesterol, often lowering HDL (good) cholesterol while raising LDL (bad) cholesterol, potentially increasing the risk of arteriosclerosis. The extent of these effects varies based on dosage, administration route, and whether the steroid aromatizes. Research indicates that administering 600mg of nandrolone decanoate weekly for ten weeks resulted in a 26% decrease in HDL cholesterol—slightly surpassing the impact of testosterone enanthate. While nandrolone decanoate causes a more pronounced negative change in lipid profiles compared to testosterone cypionate, it is still milder in effect than c-17 alpha alkylated agents. Other cardiovascular risks associated with anabolic steroids include elevated blood pressure and triglycerides.

Blakusparādības (testosterona nomākšana)

All anabolic and androgenic steroids can suppress endogenous testosterone when dosed for muscle gain. Studies show that 100mg of nandrolone decanoate weekly for six weeks reduced testosterone levels by approximately 57%, and at 300mg, the reduction reached 70%. Nandrolone’s progestational activity contributes significantly to this suppression. Without testosterone-stimulating interventions, normal testosterone levels can typically be restored within 2-6 months post-use, although prolonged hypogonadotropic hypogonadism may require medical attention.

Administrācija (Vīrieši)

For anabolic benefits, early guidelines suggested 25-50mg weekly for 12 weeks, with performance enhancement often ranging from 200-400mg per week in 8-12 week cycles. Given the rapid action of the phenylpropionate ester, doses are usually split into two evenly spaced applications each week.

Administration (Women)

Early guidelines also recommend 25-50mg weekly for 12 weeks for general anabolic effects. Commonly, a 50mg single weekly injection is used for enhancement cycles lasting 4-6 weeks. Due to potential virilization risks, longer or higher doses should be approached cautiously, with immediate discontinuation advised if such symptoms arise.