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Tadalafil - Cialis

Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor categorized as a medication for erectile dysfunction and pulmonary arterial hypertension (traded as Adcirca).

Discover the essential features of Tadalafil.

Mechanism of Action

• By inhibiting the enzyme PDE5, Tadalafil prevents the breakdown of cyclic guanosine monophosphate (cGMP).
• During sexual arousal, nitric oxide (NO) boosts cGMP levels, facilitating smoother muscle relaxation in the blood vessels of the penis.
• This enhances blood flow, allowing for effective erection and maintenance.

Indicaties

• Tadalafil is mainly prescribed for treating erectile dysfunction.
• It also addresses benign prostatic hyperplasia (BPH) and is indicated in the treatment of pulmonary arterial hypertension through Adcirca.

Onset of Action

• The onset of Tadalafil occurs swiftly, usually within 30 minutes to 1 hour after ingestion.

Duration of Action

• The effects of Tadalafil can extend up to 36 hours, earning it the nickname “weekend pill.”
• This duration allows men to achieve and maintain an erection upon sexual stimulation.

Dosering

• The standard dosage for erectile dysfunction is between 10 mg to 20 mg, taken approximately 30 minutes before sexual activity.
• For managing BPH, a daily dose of 5 mg is typically recommended.

Bijwerkingen

• Common side effects may include headache, facial flushing, indigestion (like nausea or diarrhea), dizziness, muscle pain, and backache.
• In rare instances, serious effects such as sudden vision or hearing loss can occur.

Contra-indicaties

• Tadalafil must not be taken concurrently with nitrates (e.g., nitroglycerin), due to the risk of significant blood pressure drops.
• It’s contraindicated in individuals with severe heart issues, recent heart attacks, or strokes.