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Sildenafil

Sildenafil is a leading medication in the class of phosphodiesterase type 5 (PDE5) inhibitors, widely recognized under the brand name Viagra.

Discover the key characteristics of Sildenafil:

• Mechanism of Action: Sildenafil inhibits the phosphodiesterase type 5 (PDE5) enzyme, which typically degrades cyclic guanosine monophosphate (cGMP). Upon sexual arousal, nitric oxide (NO) release enhances cGMP levels, leading to the relaxation of smooth muscles in blood vessels and increased blood flow to the penis, facilitating erection.
• Indications: Primarily used for treating erectile dysfunction in men, it can also be indicated for treating pulmonary arterial hypertension under the name Revatio.
• Onset of Action: The effects of Sildenafil typically begin within 30 minutes; however, onset may extend to 1 hour in some cases.
• Duration of Action: The efficacy lasts between 4 to 5 hours, providing ample time for achieving and sustaining an erection.
• Dozaj: The standard starting dose for Sildenafil is 50 mg, subject to adjustment based on individual efficacy and tolerance. It is recommended to be taken 30 minutes to 1 hour before engaging in sexual activities.
• Side Effects: Commonly reported side effects include headache, flushing, dyspepsia (e.g., nausea, diarrhea), visual disturbances (e.g., blurred vision, color perception changes), elevated blood pressure, and in rare instances, auditory complications.
• Contraindications: Avoid concurrent use with nitrates (like nitroglycerin) due to risks of significant hypotension. Contraindicated in patients experiencing severe cardiac conditions, recent heart attacks, or strokes.