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Sildenafil

Sildenafil is a well-known medication categorized as a phosphodiesterase type 5 (PDE5) inhibitor, commonly recognized by its brand name, Viagra.

Discover the key aspects of sildenafil:

Mechanism of Action

• Sildenafil inhibits the enzyme phosphodiesterase type 5 (PDE5), preventing the breakdown of cyclic guanosine monophosphate (cGMP). When sexual stimulation occurs, nitric oxide (NO) is released in the penile tissues, leading to elevated cGMP levels, which relaxes smooth muscles in blood vessels and enhances blood flow to the penis.
• This process facilitates the achievement and maintenance of an erection.

Indikationer

• Sildenafil is primarily indicated for treating erectile dysfunction in men.
• It is also available under the name Revatio for treating arterial hypertension.

Onset of Action

• The onset of sildenafil’s effects is typically rapid, usually occurring within 30 minutes but may extend to an hour for some individuals.

Duration of Action

• Sildenafil’s effects typically last between 4 to 5 hours, allowing sufficient time to achieve and sustain an erection.

Dosering

• The recommended starting dose of sildenafil is 50 mg, adjustable based on individual response.
• It is advised to take the dose approximately 30 minutes to 1 hour before anticipated sexual activity.

Biverkningar

• Common side effects include headache, facial flushing, indigestion (nausea, diarrhea), visual disturbances (blurred vision, color perception shifts), increased blood pressure, with rare occurrences of hearing loss.

Kontraindikationer

• Sildenafil should never be taken with nitrates (like nitroglycerin) due to the risk of a severe blood pressure drop. It is contraindicated for individuals with serious heart conditions, recent heart attacks, or strokes.