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Sildenafil

Sildenafil is a medication classified under PDE5 inhibitors, commonly recognized by its brand name, Viagra.

Key Features of Sildenafil:

Mechanism of Action

• Sildenafil inhibits the enzyme PDE5, preventing the breakdown of cGMP. This process enhances nitric oxide release during sexual arousal, leading to increased blood flow and relaxation of penile smooth muscles.
• This mechanism facilitates the achievement and maintenance of erections.

Indikationer

• Sildenafil is primarily indicated for treating erectile dysfunction in men.
• It is also recommended for managing arterial hypertension under the name Revatio.

Onset of Action

• The onset of Sildenafil’s effects typically occurs within 30 minutes, although it may take up to 1 hour for some users.

Duration of Action

• The efficacy of Sildenafil lasts approximately 4 to 5 hours, sufficient for maintaining an erection.

Dosering

• The standard initial dose is 50 mg, adjustable based on individual needs and responses.
• This dose should be taken roughly 30 minutes to 1 hour before planned sexual activity.

Biverkningar

• Common adverse effects include headaches, facial flushing, dyspepsia, visual disturbances, elevated blood pressure, and, infrequently, hearing loss.

Kontraindikationer

• Combination with nitrates (e.g., nitroglycerin) is prohibited due to the risk of severe hypotension. It’s also contraindicated in individuals with serious cardiac issues or recent myocardial infarction or stroke.