Euro-Pharmacies T3+T4 150 mcg bag 50 tabs (30 + 120 mcg/tab)

Liothyronine – Cytomel

Thyroid hormones are vital for our bodies, produced naturally but often synthesized for pharmaceutical use. The primary forms are T4, recognized as levothyroxine, and T3, known as liothyronine. These hormones are manufactured and stored within the thyroid gland.

Pharmaceutical-grade thyroid hormones are produced either from animal thyroid glands (bovine or ovine sources) or through synthetic processes. In the USA, strict regulations ensure the iodine content in these preparations is consistent.

Cytomel (liothyronine sodium) is available in tablet form, representing a potent form of the natural thyroid hormone. T3 has a significantly greater potency compared to T4.

Фармакологія

The precise mechanisms of thyroid hormone action are not fully understood, but they initiate numerous biochemical changes at the cellular level, significantly impacting energy metabolism. These hormones enhance the utilization of carbohydrates, lipids, and proteins while increasing oxygen consumption, leading to a higher basal metabolic rate. They influence almost every organ, including the brain, and their importance becomes evident when examining patients with hormone deficiencies.

Дозування

Thyroid hormone is readily absorbed into the bloodstream from the stomach, delivering rapid onset of effects—typically within hours—while peak activity may take several days. The hormone has a considerable retention period in the body due to its binding with albumin, which protects it from liver breakdown.

• As a replacement therapy for individuals with hypothyroidism.
• Post-surgical thyroid removal replacement therapy.
• Treatment for individuals with goiters and thyroid nodules.
• Diagnostic use in suppression tests for suspected hyperthyroidism.
• For those with allergies to bovine or porcine thyroid, Cytomel serves as an alternative.

Бодібілдери та схуднення

For years, both amateur and professional athletes have misused thyroid hormones for weight loss. By enhancing fat and carbohydrate metabolism, Cytomel has been a common choice across various sports. Typically taken orally for 4-6 weeks, athletes often cease usage one week before competitions to maximize results. A number of athletes claim significant weight loss and increased energy from short-term Cytomel use.

However, this becomes complicated as athletes may also be using various other supplements and hormones in their regimen.

Online vendors suggest starting with a dosage of 25 mcg/day for a few weeks, increasing by 5-10 mcg/day gradually, with a maximum advised dose of 100 mcg/day. Reports from athletes indicate that weight loss with Cytomel may take 6-12 weeks. It is crucial to note that discontinuation can lead to thyroid insufficiency if not tapered properly.

Ознаки та симптоми

Excessive thyroid hormone may cause side effects such as:

• Headaches
• Mood swings – irritability, anxiety
• Excessive sweating
• Порушення серцевого ритму
• Heart palpitations
• Біль у грудях
• Діарея
• Порушення менструального циклу
• Worsening heart failure
• Шок.

Overdosage may mimic thyroid storm symptoms, while chronic overuse can lead to hyperthyroidism.

Протипоказання

Thyroid hormones should be avoided by individuals with untreated adrenal insufficiency, untreated thyrotoxicosis, or hypersensitivity to any components. Genuine allergic reactions to liothyronine remain rare.

Additional Considerations

Many people misuse thyroid hormones for weight loss, often in combination with other substances. Typically, lower therapeutic doses are ineffective for weight loss, necessitating larger, dangerous doses which may present life-threatening risks, particularly when combined with agents like ephedrine or growth hormone.

Caution is advised in specific medical conditions; thyroid hormones can complicate adrenal insufficiency or diabetes. They may also heighten sensitivity to anticoagulants, increasing bleeding risk.

Thyroid hormones are sometimes suggested for infertility without scientific backing, and they carry significant risks. Individuals with cardiac issues should consult their physician before initiating therapy.

Рівні

Athlete thyroid hormone levels are routinely monitored in compliance with regulations from organizations like the IOC and WADA, using sensitive radioimmunoassays to detect trace amounts.

Взаємодія з лікарськими засобами

Liothyronine may interact with various medications pertaining to:

• Oral anticoagulants
• Insulin or oral hypoglycemics
• Cholestyramine
• Estrogen, oral contraceptives
• Tricyclic antidepressants
• Digitalis

It is vital for physicians to monitor dosages, and all users should undergo regular follow-ups.

Лікування передозування

In cases of suspected thyroid hormone overdosage, hospital admission is necessary. Hormone intake should cease, and patients monitored closely. Recovery may take 4-8 weeks; no specific antidotes exist, and care is primarily supportive. Inducing vomiting should be avoided due to aspiration risks. Comatose patients may require mechanical ventilation in intensive care. Standard treatment includes fluid resuscitation, oxygen, and monitoring, with beta-blockers administered when necessary.

Дозування

Liothyronine is taken daily in tablet form, and dosage is contingent on the severity of hypothyroidism. It is essential to begin therapy at the lowest effective dose due to the swift onset of effects. The standard starting dose for Cytomel is 5 mcg/day, with gradual increases of no more than 5 mcg/day at 2-3 week intervals. High or abrupt increases can exacerbate any pre-existing heart conditions. Most cases require dosages ranging between 50-75 mcg/day. Liothyronine is also available intravenously for urgent conditions like myxedema coma, a severe complication of hypothyroidism, predominantly affecting elderly women.

Liothyronine tablets are available in 5, 25, and 50 mcg strengths, requiring a doctor’s prescription in the USA.

T4 – Liothyronine Sodium

This synthetic thyroid hormone, commonly called levothyroxine, is utilized primarily for hypothyroidism treatment. T4 is a synthetic replication of the hormones produced by the thyroid gland, offering positive impacts on the central nervous system, fat metabolism, cellular functions, and overall well-being.

Дозування

100 - 300 mcg на день

Ефекти

Athletes may enhance physical performance and lose weight effectively with T4, experiencing reduced hunger.

Побічні ефекти

Common adverse effects associated with T4 include insomnia, tremors, anxiety, irregular heartbeat, and suppression of natural thyroid hormone production.

Захист

To minimize side effects, incorporate beta-adrenoblockers and ketotifen in the regimen. It’s advisable to take T4 in the morning to prevent insomnia.

Укладання

Extra caution is necessary when combining T4 with other medications that affect blood pressure and heart rate.