Pfizer Genotropin 1 vial (1x 36 IU)

HGH – human growth hormone

Human growth hormone, or GH, is a crucial substance produced by the anterior pituitary gland, vital for effective growth and development. Its secretion begins at birth, peaking during late adolescence, and gradually declines beginning in the second decade of life. For over 40 years, growth hormone has been utilized to treat specific medical conditions. Recently, there is an overwhelming demand for GH, particularly among middle-aged and elderly individuals who believe it may reverse aging, teenagers aiming to enhance their physiques, and athletes seeking competitive advantages. Abuse of GH ranks among the top three drugs among sports figures.

What is Human Growth Hormone?

Also recognized as hGH, GH is responsible for stimulating cell production, growth, and metabolism in the body. It functions alongside other hormones to regulate essential human development processes. GH levels peak at puberty and show a notable decline around age 40. Available in health stores, spas, and from various health practitioners, GH is often marketed under names like Genotropin®, Humatrope®, Norditropin®, Nutropin®, Saizen®, and Serostim®.

药理学

Most GH on the market uses recombinant DNA technology, specifically two synthetic types: somatropin and somatrem. Their pharmacological actions closely resemble those of natural GH, with both forms acting by binding to GH receptors, triggering various cellular responses. Physiologically, GH regulates metabolism, maintains fluid balance, and boosts muscle and skeletal mass, with levels spiking during stress, sleep, and exercise.

在什么情况下 GH 水平会发生变化？

Abnormal GH levels can result in multiple health issues. Excess GH can lead to acromegaly, marked by enlarged extremities and rapid cell growth, or pituitary gigantism, causing extraordinary height. Conversely, GH deficiency can lead to severe health implications and short stature.

Approved Clinical Uses of GH

The FDA has authorized several injectable GH preparations, available solely through physician prescriptions. Initially approved in 1985 for treating GH deficiency related to short stature, its approvals have expanded to conditions like Prader-Willi syndrome, chronic renal insufficiency-related short stature, Turner syndrome, idiopathic short stature, and intrauterine growth retardation. GH therapy is also sanctioned for adults experiencing AIDS wasting syndrome. Evidence supports that GH injections can lead to:

• 增加肌肉质量和骨密度
• reduced body fat
• enhanced cognition
• improved physical performance
• better cardiovascular response to stress/exercise

用量

GH is exclusively administered via injection—subcutaneously or intramuscularly—and acts rapidly post-absorption. Dosage guidelines vary, though adult dosing typically ranges from 0.01-0.1 mg/kg body weight, depending on product type and intended purpose. GH is available in both powder and liquid forms, requiring solubilization in saline before injection.

Side Effects of Growth Hormone

GH may cause several alarming side effects, including:

• 全身水肿
• 腕管综合征
• joint and muscle discomfort
• neuropathies (e.g., numbness, tingling)
• increased blood glucose levels

GH 需要处方吗？

Legally, GH is prescribed solely for FDA-approved indications; however, off-label uses, such as performance enhancement and anti-aging, are prevalent. Often, off-label usage is not endorsed by the FDA due to an unfavorable risk-benefit ratio. While some consider GH a miraculous solution, it possesses significant side effects warranting caution before commencing treatment.

Potential Risks of Taking GH

Risks include overdose, potentially leading to severe conditions like acromegaly and activation of undesired cell proliferation, including carcinogenesis. Less severe side effects may include fluid retention and carpal tunnel syndrome, while anti-aging seekers must diligently weigh treatment risks against potential benefits.

Off-Label Use

健美GH is prominently misused for bodybuilding and anti-aging, with its illegal status amplifying its abuse among athletes. Determining the effectiveness of GH is challenging due to the concurrent use of numerous substances. Monthly costs for GH can vary greatly, ranging from $500 to $2000, with some products being counterfeit.

Anti-Aging

Despite its popularity, GH is not FDA-approved for anti-aging purposes, and no evidence supports its efficacy in reversing wrinkles or enhancing skin texture. The hype surrounding it has spawned a $70 million market for ineffective alternatives, with real GH injections costing consumers upwards of $10,000 annually.

可用性

Many individuals procure GH through illegal channels, including theft from pharmacies and unscrupulous prescriptions from physicians. Online pharmacies often dispense GH without proper medical oversight. Despite legitimate administration being via injection, many products falsely marketed as sprays or gels offer minimal absorption.

Limitations of Testing

Detecting synthetic GH is challenging, with current methods only identifying its presence within 48 hours post-injection, leading many athletes to exploit this loophole.

舍莫瑞林

Sermorelin, a counterfeit from Geref, stimulates GH release from the anterior pituitary. It remains undetectable in blood or urine for a certain period, highlighting ongoing challenges in doping control. While it takes 3-4 weeks for effects to manifest and lacks the severe side effects associated with GH, it is not a viable substitute for individuals with GH deficiency. Sermorelin is priced between $300 to $1000 monthly.

控制状态

The mounting abuse of GH has prompted Federal Regulations to restrict its sale. Penalties for illegal possession or distribution of GH can include jail time and fines. The 2007 Senate bill aimed to classify GH as a schedule III substance, recognizing it as a performance-enhancing drug by entities like the World Anti-Doping Agency and the International Olympic Committee.